Tianeptine Restrictions

Tianeptine falls into a grey area when it comes to U.S. substance control. Although the legality can be questioned, it is not listed as a federally controlled substance. However, restrictions have been placed on the local Tianeptine market, and certain states have imposed restrictions that should be worth noting before considering purchasing any Tianeptine online.

What is Tianeptine?

Initially developed in the 1980s as an alternative treatment for depression, Tianeptine is currently classified as an atypical tricyclic antidepressant due to its mechanism of action and unique molecular structure. Initially, Tianeptine was thought to work by enhancing serotonin uptake. However, research has emerged showing Tianeptine has a low affinity for serotonin transporters and does not significantly impact serotonin neurotransmission. Instead, the antidepressant effects are hypothesized to be a result of glutamate modulation.

How Does Tianeptine Work?

Research seems to point to the ability of Tianeptine to stabilize glutaminergic signalling. This results in Tianeptine exerting an effect on N-methyl-D-aspartate (NMDA) and aminomethylphosphonic acid (AMPA) receptors. Additionally, Tianeptine acts as a full agonist at mu opioid receptors and a weak agonist at delta opioid receptors. The activation of Mu opioid receptors may lead to downstream stimulation of the glutaminergic pathway, thereby resulting in the therapeutic effects. At higher research doses, Tianeptine’s action at these Mu opioid receptors can also have the potential to trigger dopamine release and produce opioid-like feelings of euphoria.

Tianeptine’s opioid-like effects give it significant potential for misuse and abuse. As a result, researchers should be responsible for ensuring ethical research practices when working with Tianeptine. Iron Mountain Labz sells all forms of Tianeptine strictly for research purposes.