Description
AC-Selank NH2
Disclaimer: The compounds described on this page are intended for laboratory research use only and are not approved for human consumption.
Overview of AC-Selank NH2
AC-Selank NH2 (N-Acetyl Selank Amidate) is a synthetic heptapeptide and a structurally enhanced analog of Selank, itself derived from the endogenous immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg).
The parent compound Selank incorporates a C-terminal Pro-Gly-Pro (PGP) extension to improve metabolic stability.
AC-Selank NH2 further introduces N-terminal acetylation and C-terminal amidation, conferring enhanced resistance to enzymatic hydrolysis and extended receptor interaction profiles compared to the unmodified parent peptide.
AC-Selank NH2 is studied in preclinical research settings for its interaction with GABAergic neurotransmission pathways, serotonergic signaling networks, and immunomodulatory receptor systems.
Investigational research has explored its role in neuroendocrine signaling regulation, neurotrophin expression, and inflammatory cascade modulation in controlled laboratory environments.
| Section | Details |
| CAS Number | 2212313-10-6 |
| Molar Mass | 793.9 g/mol |
| Chemical Formula | C₃₅H₅₉N₁₁O₁₀ |
| Sequence | Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH₂ (TKPRPGP) |
| IUPAC Name | (2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3R)-2-acetamido-3-hydroxybutanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxamide |
| Synonyms | N-Acetyl Selank Amidate, AC-THR-LYS-PRO-ARG-PRO-GLY-PRO, N-Acetyl Selank |
| Ingredients / Composition | AC-Selank NH2 compound as key component with a purity of 98.8% |
| Shelf Life | 2 years |
| Storage Instructions | Store as lyophilized powder at –18°C or below, protected from light and moisture |
| Disclaimer | AC-Selank NH2 is not approved for use outside of controlled laboratory research settings. It is legal for research purposes only. |
Why Consider AC-Selank NH2 for Research?
Researchers may consider AC-Selank NH2 based on its intended research application, available specifications, and supporting documentation.
- Vendor-reported purity of AC-Selank NH2: 99.6%. Review the vendor’s certificate of analysis for the batch.
- The assay result of this product meets research-grade standards at 98.8%.
- A Certificate of Analysis (COA) is also provided for verification.
Frequently Asked Questions
Is AC-Selank NH2 legal in the United States?
AC-Selank NH2 is a research chemical. It is not approved by the FDA for use outside of controlled laboratory settings in the United States.
How does AC-Selank NH2 work in research models?
AC-Selank NH2 is investigated for its interaction with GABAergic receptor systems, where preclinical data suggest modulation of inhibitory postsynaptic signaling cascades. Investigational findings associate the compound with serotonergic pathway regulation and tuftsin receptor engagement, influencing downstream immunomodulatory and neurotrophic signaling networks. The N-terminal acetylation and C-terminal amidation modifications confer enhanced resistance to aminopeptidase and carboxypeptidase enzymatic degradation, prolonging the compound’s investigational activity profile in preclinical settings.
What are the observed effects of AC-Selank NH2 in experimental settings?
Preclinical research associates AC-Selank NH2 with modulation of GABAergic inhibitory signaling, regulation of serotonergic receptor transmission, and attenuation of inflammatory cytokine cascade activity in controlled investigational settings. Research also suggests involvement in neurotrophin expression pathways and neuroendocrine feedback loop regulation in in vitro and in vivo preclinical models.
What are the noted adverse variables of AC-Selank NH2 in research settings?
Comprehensive long-term data on AC-Selank NH2 remains limited, and further systematic investigation is required to fully characterize its adverse variable profile. Preclinical observations note potential variability in GABAergic receptor sensitivity under prolonged investigational exposure, possible modulation of serotonergic feedback dynamics, and concentration-dependent off-target receptor interactions at elevated research concentrations.
Where can readers find vendor information for AC-Selank NH2?
Iron Mountain Labz provides research information and affiliate purchasing pathways but does not directly sell, manufacture, warehouse, or ship AC-Selank NH2. Readers should assess third-party suppliers independently and review available identity, purity, and batch-testing documentation.
IML Affiliate Disclosure
Some links on IML may connect readers with third-party suppliers through affiliate arrangements. IML may receive compensation from qualifying transactions at no additional cost to the reader, but the third-party supplier remains responsible for the actual sale, fulfillment, and product documentation.
