Description
Vitamin B12 Cyanocobalamin Injection USP 1 mg/mL | 10 mL Vial Research Overview
Disclaimer: The compounds described on this page are intended for laboratory research use only and are not approved for human consumption.
Overview of Vitamin B12 (Cyanocobalamin) Injection
Cyanocobalamin injection is an FDA-approved sterile solution of synthetic vitamin B12 supplied at 1 mg/mL (1000 mcg/mL) in a 10 mL multi-dose vial. It is the parenteral form of cobalamin studied for its role in correcting vitamin B12 deficiency states caused by malabsorption, including pernicious anemia and related gastrointestinal conditions. Parenteral administration bypasses the intrinsic factor pathway, delivering cobalamin directly into circulation in research and clinical models where oral absorption is unreliable.
Cyanocobalamin
Cyanocobalamin is a synthetic corrinoid compound the stable, pharmaceutical-grade form of vitamin B12 in which a cyano group occupies the upper axial ligand position of the cobalt-containing corrin ring. It is the most widely used parenteral cobalamin form in clinical practice due to its established stability profile and long-established pharmacokinetic characterization. Cyanocobalamin is studied in biochemical research for its role as a coenzyme precursor in two essential metabolic reactions: the methionine synthase reaction relevant to DNA synthesis and methylation, and the methylmalonyl-CoA mutase reaction relevant to fatty acid and amino acid metabolism.
Cyanocobalamin Chemical Properties
| Section | Details |
| CAS Number | 68-19-9 |
| PubChem CID | 165339223 |
| Molar Mass | 1355.37 g/mol |
| Chemical Formula | C₆₃H₈₈CoN₁₄O₁₄P |
| NDC | 0143-9620-10 |
| Chemical Class | Corrinoid (cobalt-containing coenzyme compound) |
| Concentration | 1 mg/mL (1000 mcg/mL) |
| Fill Volume | 10 mL multi-dose vial |
| Physical Form | Sterile aqueous solution |
| pH Range | 4.5–7.0 (verify per manufacturer COA) |
| Purity | ≥98% per lot (method per COA) |
| Storage | Protect from light; store per manufacturer label |
| Shelf Life | Per manufacturer expiration dating |
| Regulatory Status | FDA-approved prescription drug (Rx) Cyanocobalamin Injection, USP |
| Compound’s Disclaimer | This is an FDA-approved prescription pharmaceutical. Sale, dispensing, and administration must follow applicable federal and state prescribing and pharmacy regulations. Not for unsupervised self-administration. |
Vitamin B12 (Cyanocobalamin) Injection’s Mechanism of Action
Cyanocobalamin is absorbed rapidly following intramuscular injection, bypassing the intrinsic factor-dependent absorption pathway that fails in malabsorption states, with plasma levels peaking at approximately one hour post-injection. It is transported through circulation by transcobalamin I and II proteins to body tissues, with the liver serving as the primary storage site. At the biochemical level, cobalamin functions as a coenzyme in the methionine synthase reaction supporting DNA synthesis and methylation and in the methylmalonyl-CoA mutase reaction, which supports fatty acid and amino acid metabolism.
Why Consider Vitamin B12 (Cyanocobalamin) Injection for Research?
Researchers may consider Vitamin B12 (Cyanocobalamin) Injection based on its intended research application, available specifications, and supporting documentation.
- Purity confirmed at ≥98% per lot, with method specified on Certificate of Analysis.
- Identity confirmed per lot; structural and identity data available on COA.
- Sourced and handled in accordance with applicable pharmaceutical regulations.
- Certificate of Analysis available on request per lot.
- Detailed COA documentation supports procurement compliance for licensed providers and institutions.
For queries, complaints, or support, please contact help@ironmountainlabz.com
Frequently Asked Questions
Is Vitamin B12 (Cyanocobalamin) Injection legal in the United States?
Yes. Cyanocobalamin Injection, USP is an FDA-approved prescription pharmaceutical. It is legal for use when prescribed by a licensed healthcare provider and dispensed through a licensed pharmacy in accordance with applicable federal and state regulations. It is not sold for unsupervised self-administration.
What does Cyanocobalamin Injection do in research and clinical models?
Cyanocobalamin injection is studied for its role as a parenteral cobalamin source in models of vitamin B12 deficiency caused by malabsorption. In clinical research, it has been characterized as correcting B12 deficiency states where oral supplementation is insufficient, including pernicious anemia and post-surgical malabsorption conditions, by delivering cobalamin directly into circulation independent of intrinsic factor.
Is Cyanocobalamin Injection safe for use under medical supervision?
Cyanocobalamin has a well-characterized safety profile established through decades of approved clinical use. Hypersensitivity reactions, including rare anaphylaxis, are documented and administration should occur in a setting equipped to manage such responses. Dosing and administration schedule must be determined by a licensed healthcare provider based on the patient’s clinical presentation and laboratory findings.
What are the storage instructions for this injection?
Store protected from light at the temperature range specified on the manufacturer’s label commonly room temperature or refrigerated depending on the specific formulation. Inspect for particulate matter or discoloration before each use and discard if either is present. Use aseptic technique when withdrawing doses from the multi-dose vial.
Where can readers find vendor information for Vitamin B12 Cyanocobalamin Injection USP 1 mg/mL | 10 mL Vial?
Iron Mountain Labz provides research information and affiliate purchasing pathways but does not directly sell, manufacture, warehouse, or ship Vitamin B12 Cyanocobalamin Injection USP 1 mg/mL | 10 mL Vial. Readers should assess third-party suppliers independently and review available identity, purity, and batch-testing documentation.
References
- National Institutes of Health, Office of Dietary Supplements. Vitamin B12 – Health Professional Fact Sheet. https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/
- NCBI Bookshelf (StatPearls). Cyanocobalamin. https://www.ncbi.nlm.nih.gov/books/NBK555964/
- U.S. FDA / DailyMed. Cyanocobalamin Injection, USP Drug Label. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a66eb3c4-3e1d-4d49-b963-4fa2334cc9b6
IML Affiliate Disclosure
Some links on IML may connect readers with third-party suppliers through affiliate arrangements. IML may receive compensation from qualifying transactions at no additional cost to the reader, but the third-party supplier remains responsible for the actual sale, fulfillment, and product documentation.
