Humanin Peptide

Description

Disclaimer: This product is supplied by Iron Mountain Labz strictly for controlled laboratory research use only. It is not intended for human or veterinary consumption.

Compound Overview

Humanin is a 24-amino acid peptide encoded by the mitochondrial genome, originally identified as a member of the mitochondrial-derived peptide (MDP) family. In laboratory research settings, this peptide has been investigated for its interactions with intracellular protein complexes, cellular stress response pathways, and metabolic signaling

mechanisms.

In preclinical research models, Humanin has been studied for its binding interactions with members of the Bcl-2 protein family, its modulation of cellular survival pathways through receptor-mediated mechanisms, and its interaction with insulin-like growth factor

binding protein-3 (IGFBP-3) in cell-free binding studies.

Humanin is not a SARM, not a hormone analog, and not a dietary supplement. It is not approved by the FDA for human or veterinaryuse and is intended strictly for laboratory research purposes.

Chemical Properties of the Compound

 

Property	Detail
Product Type	Mitochondrial-Derived Peptide
Product Name	Humanin Peptide
Vial Format	5mg Lyophilized Vial
Application	Scientific / Research Use Only
CAS Number	330936-69-1
Molecular Weight	2,687.20 g/mol
Chemical Formula	C₁₁₉H₂₀₄N₃₄O₃₂S₂
PubChem CID	16131438
Peptide Length	24 amino acids
Sequence	MAPRGFSCLLLLTSEIDLPVKRRA
Peptide Source	Mitochondrial 16S rRNA open reading frame
Synonyms	HN, Humanin (HN), Mitochondrial-Derived Peptide (MDP), HNG, MAPH
Ingredients / Composition	Humanin, ≥98% purity (HPLC verified)
Physical Form	White to off-white lyophilized powder
Solubility	Soluble in sterile water or dilute aqueous buffers
Shelf Life	Up to 24 months when stored under recommended conditions
Storage Instructions	Store at −20°C in a dry, dark environment; avoid repeated freeze-thaw cycles
Classification	Research Use Only (RUO)

Single Vial Supply Specifications

 

Iron Mountain Labz supplies Humanin Peptide in single-vial format optimized for individual research laboratories and small-batch preclinical work.

Vial Format Details:

• lyophilized vial (standardized research format)
• Flip-top aluminium crimp cap (sterile sealed)
• 5mg net peptide content per vial
• Vacuum-sealed for shelf life integrity
• Unique lot number per batch for traceability

Sequence Verification:

• Amino acid sequence: MAPRGFSCLLLLTSEIDLPVKRRA
• Confirmed against published Humanin reference data (mitochondrial 16S rRNA derived ORF)
• HPLC retention time matched against reference standard
• Mass spectrometry identification per specification

Format Optimization for Research Applications:

This single-vial format is optimized for:

• In vitro cell culture experiments
• Single-batch preclinical animal studies
• Small-cohort experimental work
• Individual lab procurement (1-5 vials typical)
• Quick-turnaround experimental protocols

 

Humanin Peptide s Mechanism of Action in Research Models

In preclinical cell culture systems, Humanin has been investigated as a cytoprotective signaling molecule that interacts with intracellular protein targets. Research in isolated cell preparations has documented binding to members of the Bcl-2 family, where Humanin has been observed to interfere with pro-apoptotic Bax activation in experimental cell death models.

In isolated neuronal cell systems, Humanin has been examined for its potential to modulate cell survival pathways through receptor-mediated mechanisms, with preclinical data suggesting interaction with formyl peptide receptor-like 1 (FPRL1) and additional G protein-coupled receptor subtypes in cell culture preparations.

Humanin has also been investigated for its interaction with insulin-like growth factor binding protein-3 (IGFBP-3) in cell-free binding assays, where complex formation has been documented in preclinical research. In metabolic research models, the peptide has been studied for its role in insulin signaling pathways, with rodent study data suggesting modulation of peripheral insulin sensitivity through STAT3-mediated signaling mechanisms.

In endothelial cell systems, Humanin has been examined for its interactions with oxidative stress response pathways, with documented effects on cellular markers in oxidized LDL exposure models.

Research Applications

In controlled laboratory environments, Humanin Peptide has been investigated for the following research applications:

• Mitochondrial-derived peptide signaling kinetics and structure-activity relationship (SAR) studies
• Bcl-2 family protein interaction research, particularly Bax binding studies in apoptosis pathway models
• FPRL1 receptor binding characterization in neuronal cell systems
• IGFBP-3 complex formation studies in cell-free binding assays
• Insulin signaling pathway investigation in preclinical metabolic models
• Cellular oxidative stress response research in endothelial cell preparations
• Comparative mitochondrial peptide pharmacology studies

Why Buy Humanin Peptide s from Iron Mountain Labz?

Researchers source Humanin Peptide from Iron Mountain Labz for the following reasons:

• Purity verified at ≥98% by HPLC analysis per product specification
• Physical form confirmed as white to off-white lyophilized powder passing visual inspection requirements
• Supplied as a sterile, sealed vial with flip-top aluminium crimp cap
• Amino acid sequence verified against mitochondrial Humanin reference data
• Mass spectrometry identification per CAS 330936-69-1 specification
• 24-month shelf life when stored at −20°C in lyophilized form
• Single-vial format optimized for individual laboratory research applications
• Independent third-party testing performed per batch

Note: The Peptide Single Vials category at Iron Mountain Labz also includes other research peptides for cellular signaling and preclinical research applications.

For queries, complaints, or support, contact help@ironmountainlabz.com

Risk & Handling

Humanin is a synthetic mitochondrial-derived peptide under investigation in preclinical research.

Risk Tier: MODERATE

This rating reflects Humanin’s bioactive receptor signaling activity at intracellular protein complexes, the bioactive concentrations used in preclinical research, and the need for proper handling to prevent accidental skin or inhalation exposure during reconstitution. Researchers must observe the following precautions at all times.

Handling Precautions: Humanin vials should be handled exclusively in a controlled laboratory environment by trained personnel. Use appropriate PPE at all times — nitrile gloves, lab coat, and eye protection at minimum. Avoid direct skin and eye contact during reconstitution. Avoid inhalation of lyophilized powder during weighing.

Exposure Risks: No human safety data has been established for the research-grade formulation supplied here. Long-term or chronic toxicity data do not exist for this research preparation.

Storage: Store lyophilized Humanin vials at −20°C in a dry, dark environment. Protect from light, heat, and moisture at all times. Avoid repeated freeze-thaw cycles. The vial seal should remain intact until use.

 

Frequently Asked Questions

Is Humanin Peptide s legal in the United States?

Humanin does not hold an FDA-approved indication for any clinical use. It is available for laboratory and research purposes only in the United States. Researchers must comply with all applicable federal, state, and local regulations governing the purchase and use of research compounds.

What is Humanin Peptide used for in research?

Humanin is studied in laboratory settings for its interactions with Bcl-2 family proteins, FPRL1 receptor signaling, IGFBP-3 complex formation, insulin pathway modulation, and cellular oxidative stress responses in preclinical research models.

Is Humanin Peptide s safe for human use?

No. Humanin is not approved by the FDA for human or veterinary use. It is intended strictly for laboratory research purposes only.

What is the vial format for Humanin Peptide at Iron Mountain Labz?

Humanin is supplied as 5mg lyophilized powder in a sterile, sealed vial with a flip-top aluminium crimp cap. This format maintains peptide integrity under recommended cold storage conditions and is the standard format for research-grade lyophilized peptides.

What makes Humanin different from other mitochondrial peptides?

Humanin is encoded by the mitochondrial 16S rRNA gene, making it one of the first identified mitochondrial-genome-encoded signaling peptides. Its 24-amino acid structure and documented binding interactions with Bcl-2 family proteins and IGFBP-3 distinguish it within the mitochondrial-derived peptide research category.

How long can Humanin be stored once received?

Humanin vials have a 24-month shelf life when stored at −20°C in a dry, dark environment with the seal intact. Once reconstituted, follow the batch Certificate of Analysis for specific storage recommendations.

 

References

1. Guo, B., Zhai, D., Cabezas, E., Welsh, K., Nouraini, S., Satterthwait, A.C., & Reed, J.C. (2003). Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature, 423(6938), 456–461. https://doi.org/10.1038/nature01627
2. Ying, G., Iribarren, P., Zhou, Y., et al. (2004). Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor. Journal of Immunology, 172(11), 7078–7085. https://doi.org/10.4049/jimmunol.172.11.7078
3. Ikonen, M., Liu, B., Hashimoto, Y., et al. (2003). Interaction between the Alzheimer’s survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis. Proceedings of the National Academy of Sciences, 100(22), 13042–13047. https://pmc.ncbi.nlm.nih.gov/articles/PMC240741/
4. Muzumdar, R.H., Huffman, D.M., Atzmon, G., et al. (2009). Humanin: a novel central regulator of peripheral insulin action. PLoS ONE, 4(7), e6334. https://doi.org/10.1371/journal.pone.0006334
5. Bachar, A.R., Scheffer, L., Schroeder, A.S., et al. (2010). Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress. Cardiovascular Research, 88(2), 360–366. https://doi.org/10.1093/cvr/cvq191

 

ATTENTION: All Iron Mountain Labz products are strictly for LABORATORY AND RESEARCH PURPOSES ONLY. They are not intended for human consumption, veterinary use, or any other non-research application. The FDA has not evaluated statements regarding this product, and the product is not intended to diagnose, treat, cure, or prevent any disease.

By purchasing, you agree to our Terms and Conditions. For queries, complaints, or support, contact help@ironmountainlabz.com