Astressin B 10mg

Description

Disclaimer: All Iron Mountain Labz products are only intended for laboratory research use and are not approved for human consumption.

Overview of Astressin B

Astressin B is a synthetic cyclic peptide and a potent, non-selective corticotropin-releasing factor (CRF) receptor antagonist. 

It was developed as an investigational compound to study the CRF system, which plays a central role in stress-response regulation in research models. 

Astressin B is derived from the endogenous CRF peptide and has been structurally modified to enhance receptor binding.

Astressin B is studied for its ability to block both CRF1 and CRF2 receptor subtypes in preclinical models. 

Research has explored its role in stress-related physiological responses, gastrointestinal function, and neuroendocrine signaling. Its non-selective antagonist profile makes it a useful tool for distinguishing the individual contributions of CRF receptor subtypes in experimental settings.

Iron Mountain Labz offers Astressin B in a 10mg vial format, manufactured to research-grade standards for use in controlled laboratory environments.

 

Property	Detail
Molecular Formula	C₁₈₃H₃₀₅N₄₇O₅₅
Molecular Weight	4043.7 g/mol
CAS Number	Not universally registered; compound identity confirmed by PubChem CID 73350132 (C₁₈₃H₃₀₅N₄₇O₅₅, MW 4043.7)
PubChem CID	73350132
Synonyms	Astressin-B, [D-Phe¹², Nle²¹·³⁸, C-α-MeLeu²⁷, Glu³⁰, Lys³³, C-α-MeLeu⁴⁰]-hCRF(9-41)
Type	Cyclic CRF Peptide Antagonist
Receptor Targets	CRFR1 and CRFR2 (non-selective)
Vial Size	10mg
Form	Lyophilized Powder
Shelf Life	≥24 months lyophilized under recommended conditions
WADA Status	Not listed on WADA 2026 Prohibited List. Verify via GlobalDRO.com prior to sport science research use.
Peptide Sequence	Key modifications: D-Phe¹², Nle²¹, Nle³⁸, C-α-MeLeu²⁷, Glu³⁰, Lys³³, C-α-MeLeu⁴⁰ relative to native hCRF(9-41)

Why Buy Astressin B 10mg from Iron Mountain Labz?

Researchers prefer Iron Mountain Labz for buying Astressin B 10mg due to the following reasons:

• At Iron Mountain Labz, Astressin B is tested with HPLC and confirmed at 99.6% purity.
• The assay result of this product meets research-grade standards at 98.8%.
• The endotoxin levels of Astressin B were measured at <0.5 EU/mg, which is below the specified limit.
• A Certificate of Analysis (COA) is provided for verification.

Frequently Asked Questions

Is Astressin B 10mg legal in the United States? 

Astressin B is a research chemical. It is not approved by the FDA for human consumption in the United States. It can only be legally purchased for research use in controlled laboratory settings.

How does Astressin B work in research models? 

Astressin B functions as a non-selective antagonist at both CRF1 and CRF2 receptors in research models. By competitively blocking corticotropin-releasing factor from binding to these receptor subtypes, it attenuates downstream stress-signaling cascades. Preclinical research suggests this mechanism affects the hypothalamic-pituitary-adrenal (HPA) axis, autonomic nervous system activity, and gastrointestinal motility in experimental models.

How is Astressin B used in research settings? 

Astressin B is reconstituted with sterile bacteriostatic water prior to use. In preclinical studies, it has been administered via subcutaneous or intracerebroventricular routes in research models to investigate CRF pathway involvement in stress responses and gastrointestinal function. 

What are the observed effects of Astressin B in experimental settings?

Preclinical research associates Astressin B with attenuation of stress-induced behavioral responses, modulation of colonic motility, and suppression of CRF-mediated neuroendocrine activity in research models. Investigational findings also suggest a potential role in studying anxiety-related pathways and visceral hypersensitivity models.

What are the noted variables observed in Astressin B research?

Due to the limited scope of available preclinical data, the full profile of observed variables for Astressin B is not comprehensively documented. Some studies note the need for further investigation into its long-term receptor occupancy effects, off-target interactions, and behavior across diverse research model types. Researchers are advised to review all available literature prior to use.

Where can I buy Astressin B 10mg online? 

Astressin B 10mg is available for purchase at the Iron Mountain Labz online store. Each product is held to strict purity standards and comes with a Certificate of Analysis (COA) for full research verification.