Description
Disclaimer: The compounds described on this page are intended for laboratory research use only and are not approved for human consumption.
Overview of Astressin B
Astressin B is a synthetic cyclic peptide and a potent, non-selective corticotropin-releasing factor (CRF) receptor antagonist.
It was developed as an investigational compound to study the CRF system, which plays a central role in stress-response regulation in research models.
Astressin B is derived from the endogenous CRF peptide and has been structurally modified to enhance receptor binding.
Astressin B is studied for its ability to block both CRF1 and CRF2 receptor subtypes in preclinical models.
Research has explored its role in stress-related physiological responses, gastrointestinal function, and neuroendocrine signaling. Its non-selective antagonist profile makes it a useful tool for distinguishing the individual contributions of CRF receptor subtypes in experimental settings.
The linked vendor offers Astressin B in a 10mg vial format, manufactured to research-grade standards for use in controlled laboratory environments.
| Property | Detail |
| Molecular Formula | C₁₈₃H₃₀₅N₄₇O₅₅ |
| Molecular Weight | 4043.7 g/mol |
| CAS Number | Not universally registered; compound identity confirmed by PubChem CID 73350132 (C₁₈₃H₃₀₅N₄₇O₅₅, MW 4043.7) |
| PubChem CID | 73350132 |
| Synonyms | Astressin-B, [D-Phe¹², Nle²¹·³⁸, C-α-MeLeu²⁷, Glu³⁰, Lys³³, C-α-MeLeu⁴⁰]-hCRF(9-41) |
| Type | Cyclic CRF Peptide Antagonist |
| Receptor Targets | CRFR1 and CRFR2 (non-selective) |
| Vial Size | 10mg |
| Form | Lyophilized Powder |
| Shelf Life | ≥24 months lyophilized under recommended conditions |
| WADA Status | Not listed on WADA 2026 Prohibited List. Verify via GlobalDRO.com prior to sport science research use. |
| Peptide Sequence | Key modifications: D-Phe¹², Nle²¹, Nle³⁸, C-α-MeLeu²⁷, Glu³⁰, Lys³³, C-α-MeLeu⁴⁰ relative to native hCRF(9-41) |
Why Consider Astressin B 10mg for Research?
Researchers may consider Astressin B 10mg based on its intended research application, available specifications, and supporting documentation.
- Vendor-reported purity of Astressin B 10mg: 99.6%. Review the vendor’s certificate of analysis for the batch.
- The assay result of this product meets research-grade standards at 98.8%.
- The endotoxin levels of Astressin B were measured at <0.5 EU/mg, which is below the specified limit.
- A Certificate of Analysis (COA) is provided for verification.
Frequently Asked Questions
Is Astressin B 10mg legal in the United States?
Astressin B is a research chemical. It is not approved by the FDA for human consumption in the United States.
How does Astressin B work in research models?
Astressin B functions as a non-selective antagonist at both CRF1 and CRF2 receptors in research models. By competitively blocking corticotropin-releasing factor from binding to these receptor subtypes, it attenuates downstream stress-signaling cascades. Preclinical research suggests this mechanism affects the hypothalamic-pituitary-adrenal (HPA) axis, autonomic nervous system activity, and gastrointestinal motility in experimental models.
How is Astressin B used in research settings?
Astressin B is reconstituted with sterile bacteriostatic water prior to use. In preclinical studies, it has been administered via subcutaneous or intracerebroventricular routes in research models to investigate CRF pathway involvement in stress responses and gastrointestinal function.
What are the observed effects of Astressin B in experimental settings?
Preclinical research associates Astressin B with attenuation of stress-induced behavioral responses, modulation of colonic motility, and suppression of CRF-mediated neuroendocrine activity in research models. Investigational findings also suggest a potential role in studying anxiety-related pathways and visceral hypersensitivity models.
What are the noted variables observed in Astressin B research?
Due to the limited scope of available preclinical data, the full profile of observed variables for Astressin B is not comprehensively documented. Some studies note the need for further investigation into its long-term receptor occupancy effects, off-target interactions, and behavior across diverse research model types. Researchers are advised to review all available literature prior to use.
Where can readers find vendor information for Astressin B 10mg?
Iron Mountain Labz provides research information and affiliate purchasing pathways but does not directly sell, manufacture, warehouse, or ship Astressin B 10mg. Readers should assess third-party suppliers independently and review available identity, purity, and batch-testing documentation.
IML Affiliate Disclosure
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