MK-777 Acetamoren

Description

Disclaimer: This product is supplied by Iron Mountain Labz strictly for controlled laboratory research use only. It is not intended for human or veterinary consumption.

Compound Overview

MK-777, also identified by the chemical name Acetamoren, is a non-peptide small molecule under early-stage preclinical investigation as a potential ligand for the growth hormone secretagogue receptor (GHS-R1a), commonly known as the ghrelin receptor. This compound is structurally related to the earlier ghrelin receptor agonist ibutamoren (MK-677) but represents a chemically distinct molecular entity with a different molecular formula incorporating an acetyl functional group modification.

In laboratory research settings, MK-777 has been supplied for in vitro receptor binding investigation, structure-activity relationship studies within the spiropiperidine GHS-R1a agonist chemical class, and analytical method development for non-peptide growth hormone secretagogue detection. As of 2026, MK-777 has not been the subject of peer-reviewed clinical or preclinical publication, and all investigational applications discussed are based on structural analogy to MK-677 and the documented pharmacology of related spiropiperidine derivatives.

MK-777 is not a selective androgen receptor modulator (SARM), not a peptide hormone, and not a dietary supplement. It is not approved by the FDA for human or veterinary use and is intended strictly for laboratory research purposes.

Chemical Properties of the Compound

Property	Detail
Product Type	Growth Hormone Secretagogue Receptor Ligand (Non-Peptide)
Product Name	MK-777 (Acetamoren)
Format	Liquid / Tablet / Capsule
Application	Scientific / Research Use Only
CAS Number	950841-87-9
Molecular Weight	570.7 g/mol
Chemical Formula	C₂₉H₃₈N₄O₆S
PubChem CID	Not available
IUPAC Name	Not available (compound not listed in PubChem database)
Synonyms	Acetamoren, MK777, MK 777
Ingredients / Composition	MK-777, ≥98% purity (HPLC verified)
Physical Form	White to off-white crystalline powder (tablets/capsules); clear solution (liquid)
Solubility	Soluble in DMSO; limited aqueous solubility
Shelf Life	Up to 24 months when stored under recommended conditions
Storage Instructions	Tablet / Capsule: Store at room temperature in a tightly sealed container. Protect from light, heat, and moisture. Liquid: Store refrigerated (2°C–8°C) in a tightly sealed container. Protect from light, heat, and moistur
Classification	Research Use Only (RUO)

Product Format Specifications

Iron Mountain Labz supplies MK-777 Acetamoren in three research formats optimized for diverse experimental protocols and laboratory applications.

Liquid Solution Format:

• 30 mL amber glass bottle with child-resistant cap
• 1,000 mg total MK-777 content per bottle
• 33 mg/mL concentration (precisely formulated)
• Supplied in research-grade solvent vehicle
• Optimized for in vitro cell culture applications and receptor binding assays

Tablet Format:

• 20 mg MK-777 per tablet
• Available in 27-tablet supply (540 mg total) or 54-tablet supply (1,080 mg total)
• Compressed pharmaceutical-grade tablets
• Scored for dose division if required by protocol
• Optimized for preclinical oral administration studies in animal models
• Unit-dose format enables standardized experimental dosing

Capsule Format:

• 20 mg MK-777 per capsule
• 50-capsule supply (1,000 mg total)
• Gelatin capsule shell (size 3)
• Pre-filled for consistent dosing accuracy
• Optimized for rodent oral gavage protocols
• Capsule shell dissolution enables rapid compound release

Format Selection Guidance:

The liquid formulation provides precise volumetric dosing control for in vitro receptor binding assays, cell culture concentration-response studies, and applications requiring fractional milligram dosing accuracy. Tablet and capsule formats enable standardized unit dosing in preclinical animal research requiring oral administration routes, with tablets offering mechanical division capability for dose adjustment.

MK-777 Acetamoren Mechanism of Action in Research Models

IMPORTANT RESEARCH TRANSPARENCY NOTICE: As of 2026, no peer-reviewed publications specific to MK-777 (Acetamoren) are available. The following mechanistic discussion is based on structural analogy to the parent compound MK-677 (ibutamoren) and the known pharmacology of the spiropiperidine GHS-R1a agonist chemical class. All statements represent potential investigational areas based on chemical similarity, not established data for MK-777 itself.

MK-777 is under investigation in in vitro receptor binding assays as a non-peptide ligand at the growth hormone secretagogue receptor (GHS-R1a). Based on structural similarity to MK-677, a characterized selective growth hormone secretagogue in the spiropiperidine class, MK-777 may potentially interact with this G protein-coupled receptor in comparative pharmacology studies. The spiropiperidine core structure shared with MK-677 provides the structural basis for potential GHS-R1a binding, though receptor affinity, selectivity, and functional efficacy remain uncharacterized for MK-777 in published research.

If MK-777 demonstrates functional GHS-R1a agonist activity comparable to its structural analog MK-677, it may potentially be investigated for growth hormone release mechanisms in isolated pituitary cell preparations. Preclinical studies of MK-677 have documented stimulation of the growth hormone-insulin-like growth factor I axis through daily oral administration, representing receptor-mediated activation of the somatotropic endocrine axis. Whether MK-777 demonstrates comparable oral bioavailability, duration of GH elevation, or IGF-1 response magnitude requires direct pharmacokinetic and pharmacodynamic evaluation.

Based on documented pharmacology of structurally related ghrelin receptor agonists, MK-777 may be investigated for metabolic pathway effects if functional activity is confirmed. Research on MK-677 has demonstrated effects including reversal of diet-induced catabolism through GH secretagogue receptor activation, providing context for potential metabolic research applications with spiropiperidine derivatives. These observations establish hypothetical investigational frameworks but do not confirm MK-777 biological activity.

The primary established research application for MK-777 is comparative structure-activity relationship investigation within the spiropiperidine GHS-R1a agonist chemical series. By evaluating receptor binding affinity, selectivity profiles, and functional efficacy against characterized reference compounds including MK-677, researchers can determine the pharmacological contribution of the acetyl substitution present in MK-777’s chemical structure.

Research Applications

CRITICAL RESEARCH LIMITATION NOTICE: No peer-reviewed preclinical or clinical data exists specifically for MK-777 as of 2026. The following research applications represent potential investigational areas based on structural similarity to MK-677 and the spiropiperidine GHS-R1a agonist chemical class. These are hypothetical research directions, not established uses.

Iron Mountain Labz supplies MK-777 in liquid, tablet, and capsule formats optimized for the following research applications. All applications are hypothetical pending experimental validation.

Liquid Format Applications:

– In vitro GHS-R1a receptor binding displacement assays requiring 

  precise volumetric concentration control

– Cell-based pharmacology in ghrelin receptor-transfected cell lines

– Concentration-response curve development in receptor assay systems

– Solubility and formulation characterization studies

Tablet / Capsule Format Applications:

– Comparative oral bioavailability investigation in rodent models

– Dose-normalized preclinical oral administration pharmacokinetic studies requiring standardized unit dosing

– Non-peptide secretagogue detection method development in biological matrix

If functional GHS-R1a activity is demonstrated in preliminary receptor assays, potential investigational areas based on documented MK-677 research including effects on body composition in experimental models may include growth hormone secretion mechanism studies, IGF-1 pathway characterization, and neuroendocrine signaling investigations.

Why Buy MK-777 Acetamoren from Iron Mountain Labz?

Researchers source MK-777 from Iron Mountain Labz for the following reasons:

• Purity verified at ≥98% by HPLC analysis per product specification
• Physical form confirmed for liquid, tablet, and capsule formulations passing visual inspection requirements
• Three research formats available for experimental protocol flexibility: liquid (30 mL, 33 mg/mL), tablet (20 mg, 27 or 54 count), capsule (20 mg, 50 count)
• Chemical identity verified against CAS 950841-87-9 specification through analytical testing
• Molecular identity confirmation critical for this compound given variation in vendor specifications industry-wide
• Certificate of Analysis (COA) explicitly confirming molecular formula per batch
• Mass spectrometry verification confirming molecular weight specification
• 24-month shelf life when stored at −20°C in sealed containers
• Format-specific advantages: Liquid enables precise volumetric dosing for in vitro assays; tablets and capsules provide standardized unit dosing for preclinical oral administration protocols
• Independent third-party testing performed per batch
• Secure checkout and discreet shipping for institutional and independent laboratory procurement
• Fast processing for research supply continuity

Note: The Growth Hormone Secretagogue Research Compounds category at Iron Mountain Labz also includes other non-peptide GHS-R1a ligands for comparative pharmacology and receptor characterization studies.

For queries, complaints, or support, contact help@ironmountainlabz.com 

Risk & Handling

MK-777 is an uncharacterized synthetic compound under early-stage investigation in preclinical research.

Risk Tier: HIGH

This rating reflects the complete absence of toxicological data for MK-777, unknown receptor affinity and selectivity profile, potential bioactive effects on neuroendocrine pathways if GHS-R1a activity is confirmed, elevated regulatory exposure under the Anti-Drug Abuse Act of 1988, and the additional handling considerations specific to liquid, tablet, and capsule research formats. Researchers must observe the following precautions at all times. 

Handling Precautions: MK-777 in all formulations should be handled exclusively in a controlled laboratory environment by trained personnel. Use appropriate PPE at all times — nitrile gloves, lab coat, and eye protection at minimum. For liquid formulations, use chemical-resistant gloves and avoid accidental ingestion or skin contact during pipetting operations. Avoid inhalation of powder when handling tablets or capsules. Conduct all weighing operations in a fume hood or biosafety cabinet to prevent aerosol exposure.

Exposure Risks: No human safety data has been established for the research-grade formulation supplied here. No animal safety data has been established for MK-777. Acute toxicity parameters (LD50 values) are unknown. Chronic toxicity potential is uncharacterized. Long-term or chronic toxicity data do not exist for this research preparation.

Regulatory Risk: Growth hormone is controlled under the Anti-Drug Abuse Act of 1988 and may only be distributed with valid prescription. Compounds that may interact with growth hormone secretagogue pathways carry elevated regulatory exposure. Unauthorized human use or distribution may violate federal law. Purchaser assumes all liability for federal and state law compliance.

Storage: Store all MK-777 formulations at −20°C in sealed containers in a dry, dark environment. Protect from light, heat, and moisture at all times. For liquid formulations, store upright to prevent cap seal degradation. Avoid repeated freeze-thaw cycles. Once tablets or capsules are removed from storage, allow containers to reach room temperature before opening to prevent moisture condensation.

Frequently Asked Questions

Is MK-777 Acetamoren legal in the United States?

MK-777 does not hold an FDA-approved indication for any clinical use. It is available for laboratory and research purposes only in the United States. Researchers must comply with all applicable federal, state, and local regulations governing the purchase and use of research compounds. Growth hormone secretagogue pathway compounds carry elevated regulatory exposure under the Anti-Drug Abuse Act of 1988.

What is MK-777 Acetamoren used for in research?

MK-777 is supplied for in vitro receptor binding assay development, comparative structure-activity relationship research within the spiropiperidine GHS-R1a agonist chemical series, and analytical method development. No published data confirms any biological activity for MK-777. All investigational applications are hypothetical pending experimental validation.

Is MK-777 Acetamoren safe for human use?

No. MK-777 is not approved by the FDA for human or veterinary use. It is intended strictly for laboratory research purposes only. No safety data exists for MK-777.

What formats does Iron Mountain Labz offer for MK-777?

Iron Mountain Labz supplies MK-777 in three research formats: liquid solution (30 mL, 33 mg/mL), tablet form (20 mg tablets in 27 or 54 count), and capsule form (20 mg capsules, 50 count). Format selection depends on experimental protocol requirements.

What makes MK-777 different from other growth hormone secretagogues?

MK-777 is a non-peptide spiropiperidine derivative, distinguishing it from peptide-based growth hormone secretagogues such as GHRP-2, GHRP-6, and hexarelin which require injection. The non-peptide structure may provide oral bioavailability advantages in preclinical research models if functional activity is demonstrated.

How long can MK-777 be stored once received?

All MK-777 formulations have a 24-month shelf life when stored at −20°C in sealed containers protected from light, heat, and moisture. Follow standard laboratory protocols for storage when opened  to avoid degradation.

References

Research Transparency Note: The following references relate to the parent compound class (MK-677/ibutamoren) and the ghrelin receptor pharmacology field that provides context for MK-777 research. No peer-reviewed publications specific to MK-777 are available as of 2026.

• Murphy, M.G., Plunkett, L.M., Gertz, B.J., He, W., Wittreich, J., Polvino, W.M., & Clemmons, D.R. (1998). MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. Journal of Clinical Endocrinology & Metabolism, 83(2), 320–325. https://doi.org/10.1210/jcem.83.2.4532 
• Bowers, C.Y., Momany, F., Reynolds, G.A., Chang, D., Hong, A., & Chang, K. (1995). Structure-activity relationships of a synthetic pentapeptide that specifically releases growth hormone in vitro. Endocrinology, 114(5), 1537-1545. https://pubmed.ncbi.nlm.nih.gov/7624358/ 
• Chapman, I.M., Bach, M.A., Van Cauter, E., Farmer, M., Krupa, D., Taylor, A.M., Schilling, L.M., Cole, K.Y., Skiles, E.H., Pezzoli, S.S., Hartman, M.L., Veldhuis, J.D., Gormley, G.J., & Thorner, M.O. (1996). Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretagogue (MK-677) in healthy elderly subjects. Journal of Clinical Endocrinology & Metabolism, 81(12), 4249–4257. https://doi.org/10.1210/jcem.81.12.8954023 
• Bach, M.A., Rockwood, K., Zetterberg, C., Thamsborg, G., Hebert, R., Devogelaer, J.P., Christiansen, J.S., Rizzoli, R., Ochsner, J.L., Vermeulen, A., Lauritzen, M., & Benhamou, C.L. (2004). The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture. Journal of the American Geriatrics Society, 52(4), 516-523. https://doi.org/10.1111/j.1532-5415.2004.52156.x 
• Nass, R., Pezzoli, S.S., Oliveri, M.C., Patrie, J.T., Harrell, F.E., Jr, Clasey, J.L., Heymsfield, S.B., Bach, M.A., Vance, M.L., & Thorner, M.O. (2008). Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults. Annals of Internal Medicine, 149(9), 601–611. https://doi.org/10.7326/0003-4819-149-9-200811040-00003 

ATTENTION: All Iron Mountain Labz products are strictly for LABORATORY AND RESEARCH PURPOSES ONLY. They are not intended for human consumption, veterinary use, or any other non-research application. The FDA has not evaluated statements regarding this product, and the product is not intended to diagnose, treat, cure, or prevent any disease.

By purchasing, you agree to our Terms and Conditions. For queries, complaints, or support, contact help@ironmountainlabz.com